FCER 2 ( Fc fragment of IgE , low affinity II , receptor for ( CD 23 ) )
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چکیده
Normally expressed in B-cells. Its expression has been shown on T-cells, Langerhans cells, monocytes, macrophages, platelets, and eosinophils as well. Through alternative splicing 2 major isoforms are produced, FCER2a (CD23a) and FCER2b (CD23b), both of which are expressed on B-cells. FCER2a is constitutively expressed, whereas FCER2b is induced by several cytokines, especially by IL4. There are 3 other splice forms, whose biological significance remains to be determined.
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تاریخ انتشار 2012